Endothelial Dysfunction and Cellular Adhesion Molecule Activation in Preterm Infants with Hypoxic Ischemic Encephalopathy
Huseynova Saadat, Orujova Puste, Panakhova Nushaba, Hasanov Safikhan, Alasgarova Saadat, Mukhtarova Sevinj

Abstract
Purpose: This study aimed to study changes in endothelial function and the levels of adhesion molecules in preterm infants with hypoxic ischemic encephalopathy (HIE). Methods: The newborns were placed into either the control (22 infants) or the HIE group (112 infants).The concentrations of endothelin-1 (ET-1), soluble intracellular adhesion molecule-1 (sICAM-1), soluble vascular cellular adhesion molecule-1 (sVCAM-1) and nitric oxide (NO) were examined in peripheral blood samples of infants. Results: In infants with HIE sICAM-1 and sVCAM-1 levels were significantly increased on the 7th day of life compared with the 1st day of life (p<0.05). However, ET-1 and NO concentrations tended to decline over this period, and there were statistically significant decreases in nitrate levels during the first week of life (p<0.05). Conclusion: Increased sICAM-1 levels were associated with decreased ET-1 and NO levels, potentially indicating the positive role of activated leukocyte adhesion in the mitigation of endothelial dysfunction.

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