The Influence of Obesity Induced by Monosodium Glutamate in Periodontal Tissues of Female Wister Rats with Experimental Periodontitis
Tatiane Morgenstern de Mattia, Marcela Aparecida Leite, Patrícia Oehlmeyer Nassar, Sara Cristina Sagae, Ana Claudia Paiva Alegre-Maller, Jordana Heindman Pandini, Nahana Cardoso, Vinicius Marchiori, Rose Meire Costa Brancalhão, Carlos Augusto Nassar

Abstract
Aim of the study: Evaluate the effect of obesity-induced monosodium glutamate (MSG) and female sex hormones on the periodontal tissues of Wistar rats submitted to experimental periodontitis. Methods: Thirty-three newborn Wistar rats were divided into four groups CON, OB, CONLIG e OBLIG after received subcutaneous injections of hypertonic saline solution or MSG and induced a periodontal disease. Blood, perigonate and retroperitoneal fats, gingival tissue sample and the hemimandibular were then subjected analysis. Results: Analysis showed less alveolar bone loss in the OBLIG group compared to the CONLIG group (p <0.05). In the gingival tissue analysis, no differences were found between the groups with experimental periodontitis. Conclusion: The results suggest that hypothalamic obesity may have a protective effect on alveolar bone loss in cases of induced periodontitis ,also may interfere negatively in the plasmatic concentrations of hormones LH and FSH, but there was no effect on gingival inflammation.

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